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Imaging through scattering microfluidic channels by digital holography for information recovery in lab on chip

  Articoli su Riviste JCR/ISI  (anno 2013)

Autori:  Bianco V., Paturzo M., Gennari O., Finizio A., Ferraro P

Affiliazione Autori:  CNR Istituto Nazionale di Ottica—Sezione di Napoli, Via Campi Flegrei, 34 80078 Pozzuoli (Napoli), Italy

Riassunto:  We tackle the problem of information recovery and imaging through scattering microfluidic chips by means of digital holography (DH). In many cases the chip can become opalescent due to residual deposits settling down the inner channel faces, biofilm formation, scattering particle uptake by the channel cladding or its damaging by corrosive substances, or even by condensing effect on the exterior channels walls. In these cases white-light imaging is severely degraded and no information is obtainable at all about the flowing samples. Here we investigate the problem of counting and estimating velocity of cells flowing inside a scattering chip. Moreover we propose and test a method based on the recording of multiple digital holograms to retrieve improved phase-contrast images despite the strong scattering effect. This method helps, thanks to DH, to recover information which, otherwise, would be completely lost. (C)2013 Optical Society of America

Rivista/Giornale:  OPTICS EXPRESS
Volume n.:  21 (20)      Pagine da: 23985  a: 23996
Ulteriori informazioni:  This work was supported by Progetto Bandiera \"La Fabbrica del Futuro\" in the framework of the funded project \"Plastic lab-on-chips for the optical manipulation of single cells\" (PLUS).
DOI: 10.1364/OE.21.023985

*Impact Factor della Rivista: (2013) 3.525   *Citazioni: 34
data tratti da "WEB OF SCIENCE" (marchio registrato di Thomson Reuters) ed aggiornati a:  14/07/2019

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