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In-vivo imaging of psoriatic lesions with polarization multispectral dermoscopy and multiphoton microscopy

  Articoli su Riviste JCR/ISI  (anno 2014)

Autori:  Kapsokalyvas D., Cicchi R., Bruscino N., Alfieri D., Prignano F., Massi D., Lotti T., Pavone FS

Affiliazione Autori:  European Laboratory for Non-Linear Spectroscopy (LENS) University of Florence, Sesto-Fiorentino, 50019, Italy; National Institute of Optics, National Research Council (INO-CNR), 50125, Florence, Italy; Division of Clinical, Preventive and Oncology Dermatology, Department of Critical Care Medicine and Surgery, University of Florence, 50129, Florence, Italy; Light4tech Firenze srl, 50018, Scandicci, Italy Department of Surgery and Translational Medicine, University of Florence, 50134, Florence, Italy Chair of Dermatology and Venereology, University Guglielmo Marconi, 00193, Rome, Italy Department of Physics, University of Florence, 50019, Sesto Fiorentino, Italy

Riassunto:  Psoriasis is a skin autoimmune disease characterized by hyperkeratosis, hyperproliferation of the epidermis and dilatation of dermal papillary blood vessels. Healthy skin (5 volunteers) and psoriatic lesions (3 patients) were visualized in vivo, with high contrast and resolution, with a Polarization Multispectral Dermoscope and a Multiphoton Microscope. Psoriatic features were identified and quantified. The effective diameter of the superficial blood vessels was measured at 35.2 +/- 7.2 mu m and the elongated dermal papillae had an effective diameter of 64.2 +/- 22.6 mu m. The methodologies developed could be employed for quantitative diagnostic purposes and furthermore serve as a monitoring method of the effect of personalized treatments. (C) 2014 Optical Society of America

Rivista/Giornale:  BIOMEDICAL OPTICS EXPRESS
Volume n.:  5 (7)      Pagine da: 2405  a: 2419
Ulteriori informazioni:  The authors acknowledge the contribution of R. Ballerini, A. Hajeb (Mechanical Workshop of LENS), M. Giuntini, M. De Pas, A. Montuori (Electronic Workshop of LENS), on the microscope mechanics and electronics. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreements no 228334 (OptBio) and 284464 (Bioptichal) and from the Italian Ministry for Education, University and Research in the framework of the Flagship Project NANOMAX. D. Kapsokalyvas gratefully acknowledges funding from Marie Curie Host Fellowships Action for Early Stage Research Training ATLAS programme (MEST-CT-2004-008048). Financial support by the Ente Cassa di Risparmio di Firenze (private foundation) is acknowledged.
DOI: 10.1364/BOE.5.002405

*Impact Factor della Rivista: (2014) 3.648   *Citazioni: 16
data tratti da "WEB OF SCIENCE" (marchio registrato di Thomson Reuters) ed aggiornati a:  19/05/2019

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