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Controlled antiseptic/eosin release from chitosan-based hydrogel modified fibrous substrates

  Articoli su Riviste JCR/ISI  (anno 2015)

Autori:  Romano I., Ayadi F., Rizzello L., Summa M., Bertorelli R., Pompa P.P., Brandi F., Bayer I., Athanassiou A

Affiliazione Autori:  Smart Materials, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy Department of Chemistry, University College London, London, United Kingdom The MRC/UCL Centre for Molecular and Medical Virology, University College London, London, United Kingdom Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia @UniLe, Via Barsanti 1, 730101 Arnesano, Lecce, Italy Istituto Nazionale di Ottica, CNR, Via Moruzzi 1, 56124 Pisa, Italy

Riassunto:  Fibers of cellulose networks were stably coated with N-methacrylate glycol chitosan (MGC) shells using subsequent steps of dip coating and photo-curing. The photo-crosslinked MGC-coated cellulose networks preserved their fibrous structure. A model hydrophilic antiseptic solution containing eosin, chloroxylenol and propylene glycol was incorporated into the shells to study the drug release dynamics. Detailed drug release mechanism into phosphate buffered saline (PBS) solutions from coated and pristine fibers loaded with the antiseptic was investigated. The results show that the MGC-coated cellulose fibers enable the controlled gradual release of the drug for four days, as opposed to fast, instantaneous release from eosin coated pristine fibers. This release behavior was found to affect the antibacterial efficiency of the fibrous cellulose sheets significantly against Staphylococcus aureus and Candida albicans. In the case of the MGC-eosin functionalized system the antibacterial efficiency was as high as 85% and 90%, respectively, while for the eosin coated pristine cellulose system the efficiency was negative, indicating bacterial proliferation. Furthermore, the MGC-eosin system was shown to be efficacious in a model of wound healing in mice, reducing the levels of various pro-inflammatory cytokines that modulate early inflammatory phase responses. The results demonstrate good potential of these coated fibers for wound dressing and healing applications. Due to its easy application on common passive commercial fibrous dressings such as gauzes and cotton fibers, the method can render them active dressings in a cost effective way. (C) 2015 Published by Elsevier Ltd.

Rivista/Giornale:  CARBOHYDRATE POLYMERS
Volume n.:  131      Pagine da: 306  a: 314
DOI: 10.1016/j.carbpol.2015.05.057

*Impact Factor della Rivista: (2015) 4.219   *Citazioni: 13
data tratti da "WEB OF SCIENCE" (marchio registrato di Thomson Reuters) ed aggiornati a:  19/05/2019

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