vai_a_storia   vai_a_organizzazione   vai_a_sedi   vai_a_personale   Area Riservata
    English English Version  

Liquid Crystalline Networks toward Regenerative Medicine and Tissue Repair

  Articoli su Riviste JCR/ISI  (anno 2017)

Autori:  Martella D., Paoli P., Pioner J.M., Sacconi L., Coppini R., Santini L., Lulli M., Cerbai E., Wiersma D.S., Poggesi C., Ferrantini C., Parmeggiani C

Affiliazione Autori:  European Laboratory for Non-Linear Spectroscopy, via N. Carrara 1, Sesto F. No., 50019, Italy; Dipartimento di Scienze Biomediche Sperimentali e Cliniche "Mario Serio", Università degli Studi di Firenze, Viale Morgagni 50, Firenze, 50134, Italy; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Viale Morgagni 63, Firenze, 50134, Italy; CNR-INO, via Nello Carrara 1, Sesto F. No., 50019, Italy; Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università degli Studi di Firenze, Viale Pieraccini, 6-50139, Firenze, Italy; Istituto Nazionale di Ricerca Metrologica (INRiM), Torino, 10135, Italy.

Riassunto:  The communication reports the use of liquid crystalline networks (LCNs) for engineering tissue cultures with human cells. Their ability as cell scaffolds for different cell lines is demonstrated. Preliminary assessments of the material biocompatibility are performed on human dermal fibroblasts and murine muscle cells (C2C12), demonstrating that coatings or other treatments are not needed to use the acrylate-based materials as support. Moreover, it is found that adherent C2C12 cells undergo differentiation, forming multinucleated myotubes, which show the typical elongated shape, and contain bundles of stress fibers. Once biocompatibility is demonstrated, the same LCN films are used as a substrate for culturing human induced pluripotent stem cell-derived cardiomyocites (hiPSC-CMs) proving that LCNs are capable to develop adult-like dimensions and a more mature cell function in a short period of culture in respect to standard supports. The demonstrated biocompatibility together with the extraordinary features of LCNs opens to preparation of complex cell scaffolds, both patterned and stimulated, for dynamic cell culturing. The ability of these materials to improve cell maturation and differentiation will be developed toward engineered heart and skeletal muscular tissues exploring regenerative medicine toward bioartificial muscles for injured sites replacement.

Rivista/Giornale:  SMALL
Volume n.:  13 (46)      Pagine da: 1702677  a: 1702677
Ulteriori informazioni:  The research leading to these results has received funding from the European Research Council under the European Union
DOI: 10.1002/smll.201702677

*Impact Factor della Rivista: (2017) 9.598   *Citazioni: 15
data tratti da "WEB OF SCIENCE" (marchio registrato di Thomson Reuters) ed aggiornati a:  19/05/2019

Riferimenti visionabili in IsiWeb of Knowledge: (solo per sottoscrittori)
Per visualizzare la scheda dell'articolo su IsiWeb: Clicca qui
Per visualizzare la scheda delle Citazioni dell'articolo su IsiWeb: Clicca qui

INO © Istituto Nazionale di Ottica - Largo Fermi 6, 50125 Firenze | Tel. 05523081 Fax 0552337755 - P.IVA 02118311006     P.E.C.    Info