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Functional Multichannel Poly(Propylene Fumarate)-Collagen Scaffold with Collagen-Binding Neurotrophic Factor 3 Promotes Neural Regeneration After Transected Spinal Cord Injury

  Articoli su Riviste JCR/ISI  (anno 2018)

Autori:  Chen X., Zhao YN., Li X., Xiao ZF., Yao Yj. Chu Y., Farkas B., Romano I., Brandi F., Dai JW

Affiliazione Autori:  [Chen, Xi; Dai, Jianwu] Third Mil Med Univ, Army Med Univ,Coll Prevent Med, Inst Combined Injury,Chongqing Engn Res Ctr Bioma, Chongqing Engn Res Ctr Nanomed,State Key Lab Trau, 30th Gaotanyan St, Chongqing 400038, Peoples R China. [Zhao, Yannan; Li, Xing; Xiao, Zhifeng; Dai, Jianwu] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China. [Yao, Yuanjiang; Dai, Jianwu] Third Mil Med Univ, Army Med Univ, Chongqing Key Lab Neurobiol, Dept Neurobiol, 30th Gaotanyan St, Chongqing 400038, Peoples R China. [Chu, Yun] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Suzhou 215123, Peoples R China. [Farkas, Balazs; Romano, Ilaria; Brandi, Fernando] Ist Italiano Tecnol, Via Morego 30, I-16163 Genoa, Italy. [Brandi, Fernando] CNR, Ist Nazl Ott, Via Moruzzi 1, I-56124 Pisa, Italy.

Riassunto:  Many factors contribute to the poor axonal regrowth and ineffective functional recovery after spinal cord injury (SCI). Biomaterials have been used for SCI repair by promoting bridge formation and reconnecting the neural tissue at the lesion site. The mechanical properties of biomaterials are critical for successful design to ensure the stable support as soon as possible when compressed by the surrounding spine and musculature. Poly(propylene fumarate) (PPF) scaffolds with high mechanical strength have been shown to provide firm spatial maintenance and to promote repair of tissue defects. A multichannel PPF scaffold is combined with collagen biomaterial to build a novel biocompatible delivery system coated with neurotrophin-3 containing an engineered collagen-binding domain (CBD-NT3). The parallel-aligned multichannel structure of PPF scaffolds guide the direction of neural tissue regeneration across the lesion site and promote reestablishment of bridge connectivity. The combinatorial treatment consisting of PPF and collagen loaded with CBD-NT3 improves the inhibitory microenvironment, facilitates axonal and neuronal regeneration, survival of various types of functional neurons and remyelination and synapse formation of regenerated axons following SCI. This novel treatment strategy for SCI repair effectively promotes neural tissue regeneration after transected spinal injury by providing a regrowth-supportive microenvironment and eventually induces functional improvement.

Volume n.:  7 (14)      Pagine da: 1800315  a: 1800315
Ulteriori informazioni:  Youth Innovation Promotion Association of the Chinese Academy of Sciences, 2016096. Youth Innovation Promotion Association of the Chinese Academy of Sciences, 2015077. 604263. 2016YFC1101500. 2017YFA0104704. Chinese Academy of Sciences, CAS, ZDRW-ZS-2016-2. European Geosciences Union, EGU. - X.C. and Y.Z. contributed equally to this work. This work was supported by grants from the National Key R&D Program of China (2017YFA0104704 and 2016YFC1101500), Key Research Program of the Chinese Academy of Sciences (Grant No. ZDRW-ZS-2016-2), Youth Innovation Promotion Association CAS (2015077 and 2016096), and the European Union (FP7-NMP-2013-EU-China call, grant agreement no. 604263 – NEUROSCAFFOLDS). F.B.’s corresponding email address was amended on July 25, 2018, after initial online publication.
DOI: 10.1002/adhm.201800315

   *Citazioni: 2
data tratti da "WEB OF SCIENCE" (marchio registrato di Thomson Reuters) ed aggiornati a:  14/07/2019

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