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LESM: A laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples

  Articoli su Riviste JCR/ISI  (anno 2016)

Autori:  Labate L., Andreassi M.G., Baffigi F., Bizzarri R., Borghini A., Bussolino G.C., Fulgentini L., Ghetti F., Giulietti A., K÷ster P., Lamia D., Levato T., Oishi Y., Pulignani S., Russo G., Sgarbossa A., Gizzi L

Affiliazione Autori:  Istituto Nazionale di Ottica, Consiglio Nazionale Delle Ricerche, Pisa, Italy; Istituto di Fisiologia Clinica, Consiglio Nazionale Delle Ricerche, Pisa, Italy; NEST, Istituto Nanoscienze, Consiglio Nazionale Delle Ricercheand Scuola Normale Superiore, Pisa, Italy; Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale Delle Ricerche, LATO, Cefalu, Italy; ELI-Beamlines, Institute of Physics, Czech Academy of Science, Prague, Czech Republic; Central Research Institute of Electric Power Industry, Kanagawa, Japan; Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, Italy

Riassunto:  We present a laser-driven source of electron bunches with average energy 260 keV and picosecond duration, which has been setup for radiobiological tests covering the previously untested sub-MeV energy range. Each bunch combines high charge with short duration and sub-millimeter range into a record instantaneous dose rate, as high as 10(9) Gy s(-1). The source can be operated at 10 Hz and its average dose rate is 35 mGy s(-1). Both the high instantaneous dose rate and high level of relative biological effectiveness, attached to sub-MeV electrons, make this source very attractive for studies of ultrafast radiobiology on thin cell samples. The source reliability, in terms of shot-to-shot stability of features such as mean energy, bunch charge and transverse beam profile, is discussed, along with a dosimetric characterization. Finally, a few preliminary biological tests performed with this source are presented.

Rivista/Giornale:  JOURNAL OF PHYSICS D: APPLIED PHYSICS
Volume n.:  49 (27)      Pagine da: 275401 -1  a: 275401 -9
Ulteriori informazioni:  The activity of the INO-CNR Pisa group was partially supported from the Italian Ministry of Health through the Project No. GR-2009-1608935 (Study of Radiobiological and Radiotherapic Effects of a Novel Laser-Driven Electron Accelerator, D.I. AgeNaS), from the CNR funded Italian research Network ELI-Italy (Attoseconds) and from the PRIN project (Contract No. PRIN2012AY5LEL). The Pisa authors also acknowledge contribution from the MIUR-FIRB project SPARX (Sorgente Pulsata Auto-Amplificata di Radiazione X) and the INFN gResist and Plasma-med collaborations.
DOI: 10.1088/0022-3727/49/27/275401


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