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Cardiac Imaging Group

National Institute of Optics  - European Laboratory for Non-linear Spectroscopy


The Cardiac Imaging Group is developing innovative imaging methodologies to increase the understanding of cardiac physiology. For instance, we recentlly developed an ultrafast random access multi- photon (RAMP) microscope that is used to simultaneously measure action potentials and intracellular calcium transients at multiple sites within the sarcolemma of cardiac cells. An wide-field mesoscope was also developed to optically map and manipulate action potential propagation in whole mouse hearts. The mesoscope was implemented with digital micromirror device capable of drawing arbitrarily-chosen stimulation patterns allowing precise epicardial optogenetic stimulation. Recently, a real-time manipulation of the propagating electrical wave-front has been demonstrated, opening the prospect for real-time resynchronization therapy and cardiac defibrillation.

NEWS



CONTACT



Email : sacconi@lens.unifi.it

Phone Off: +39 055 4572451

Phone Lab: +39 055 4572018 - 2019

Skype : leonardo.sacconi

Address : European Laboratory for Non-linear Spectroscopy
Via Nello Carrara 1, 50019 Sesto Fiorentino (FI), Italy